Debridement that delivers more

Remove the barriers. Recruit the closers.8-11

With its unique mechanism of debridement, Collagenase SANTYL Ointment has been shown to help wounds progress toward closure through byproducts that contribute to the migration and proliferation of fibroblasts, keratinocytes and endothelial cells.8-11



Endothelial cells

Mechanism of action

SANTYL Ointment uniquely and actively debrides by cleaving necrotic tissue at seven specific sites along the denatured collagen molecule, unlike endogenous debridement that only works at one site.5,7 While this effectively removes barriers to healing, it also aids wound progression by creating polypeptide bioactive byproducts8-11 that have been shown to signal cells associated with closure.

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Body of evidence

Both case studies and clinical evidence showing dramatic reductions in wound size demonstrate how SANTYL Ointment actively helps wounds progress toward closure.

Clinical evidence

Case studies


SANTYL Ointment has demonstrated to be compatible16 with a number of other treatments.

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Dosing calculator

Proper dosing is crucial. Simply enter wound dimensions and duration of therapy and the dosing calculator will estimate the grams needed.23

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Contact us to learn more about how debridement with SANTYL Ointment delivers more.