Collagenase SANTYL Ointment compatibility with commonly used wound care products
Previous studies have shown17, 22 the positive outcomes when using SANTYL Ointment in conjunction with other wound care products. To ensure that the collagenase enzyme in SANTYL maintains activity, in vitro testing was performed across a wide variety of commonly used products to determine compatibility. Testing did not evaluate efficacy, only the ability of collagenase to remain active and functional.
An inhibition level of 20% or less is deemed an acceptable threshold for enzymatic activity when used concomitantly with topical adjunctive therapies.25
If inhibition levels exceed 20%, collagenase enzyme activity and efficacy may be affected.
These results are from in vitro studies and are only an approximation of actual therapeutic outcomes. The decision to use a wound care product or combination of products should rest on a clinical judgement in which the perceived benefits outweigh any potential risks.
For detailed product information, including indications for use, contraindications, effects, precautions, warnings, and important safety information, please consult each product's Instructions for Use (IFU) prior to use.
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Type of Product
| ACTICOAT♢ | 52.4 | Nanocrystalline silver |
| Actisorb™ Ag | 0.0 | Silver charcoal-activated dressing |
| Algicell® | <2.0 | Silver dispersed in calcium alginate fibers |
| Algidex® Ag | 3.81 | Ionic silver alginate wound dressing |
| ALLEVYN♢ Ag | 7.6 | Ionic silver urethane wound dressing |
| Aquacel® Ag | 7.7 | Hydrofiber silver dressing |
| Aquacel® Ag Extra | 20 | Hydrofiber® Technology dressing with silver |
| Argentyn-23® | 0.4 | Colloidal Silver |
| Arglaes® | 63.8 | Silver dispersed in alginate powder |
| Biatain® Ag | <1.0 | Hydro-activated silver in soft dressing |
| BIOSTEP♢ Collagen Matrix Dressing | 36.7 | Silver dispersed in collagen matrix |
| Calcium Alginate Dressing with Silver | 0.0 | Gelling fiber silver dressing with NaHZrPO4 |
| ColActive + Ag | 34.7 | Collagen matrix dressing with silver |
| DermaGinate® Ag | 30.0 | Silver dispersed in alginate fibers |
| DURAFIBER♢ Ag Gelling Fiber Dressing | 0.4 | Cellulose-based dressing |
| Elta® SilverGel™ | 12.4 | Proprietary silver gel |
| ExcelGinate® Ag | 11.0 | Ionic silver in alginate fibers |
| Gentell® Ag | 84.0 | Calcium Alginate fibers with silver |
| Keracel® Ag | 15.4 | Gelling fiber silver dressing |
| KerraContactTM Ag | 80.0 | Silver with Oxysalts |
| Maxorb® Ag | 18.0 | Ionic silver alginate wound dressing |
| Melgisorb® | 22.8 | Silver dispersed in alginate fibers |
| Mepilex® Ag | 15.7 | Ionic silver silicone dressing |
| Normlgel® Ag | 100.0 | Silver dispersed in hydrogel |
| NovaGranTMBlue | 50.0 | Silver in a foam with MB and GV |
| Opticell Ag | 81.0 | Chitosan fibers with silver |
| Optifoam® Ag | 0.0 | Ionic silver |
| PolyMem® Ag | 1.0 | Nanocrystalline silver |
| Puracol® Ag | 24.8 | Collagen-based dressing |
| Reinforced gelling fiber Ag | 78.0 | Silver in alginate and guluronic acid |
| ReliaMed® Ag | 23.0 | Silver dispersed in alginate fibers |
| RestaTM SilverGel® | 37.0 | |
| Restore® Calcium Alginate | 9.0 | Silver dispersed in calcium alginate fibers |
| Restore® TRIACT™ Silver | 0.0 | Silver sulfate dressing |
| Silvadene® (1%) | 67.0 | 1% silver sulfadiazine in cream base |
| SilvaKollagen® Gel | 19.8 | Hydrolysate of collagen with silver oxide |
| Silvasorb® | 25.0 | Ionic silver |
| Silvercel™ | <10.0 | Silver dispersed in alginate fibers |
| Silvergel | >95.0 | Silver sol |
| Silverlon® | 44.3 | Elemental silver |
| SilverMed™ | 10.8 | Microparticulate silver in carbomer gel |
| Sorbalgon® Ag | 4.4 | Silver containing calcium alginate dressing |
| Tegaderm™ Ag | 24.0 | Silver sulfate dressing |
| TheraBond® Ag | 20.9 | Ionic silver in fiber dressing |
| TRITEC™ Ag | 13.0 | Silver dispersed in fibers |
| Biolex™ | 0.0 | Poloxamine-908 and Potassium sorbate-based cleanser |
| SAF-Clens® AF | 77.7 | Amphotheric surfactant-based cleanser |
| Sea Clens® | 42.0 | Non-ionic surfactant and EDTA-based cleanser |
| 3M™ Wound Cleanser | 76.2 | Pyridoxine and Zn-salts—based cleanser |
| Allclenz® | 68.8 | Amphotheric surfactant-based cleanser |
| Aloe Vesta® | 100.0 | Anionic and amphotheric surfactants-based cleanser |
| Anasept® Spray | 0.0 | Sodium hypochlorite-based cleanser |
| CarraKlenz™ | 100.0 | Anionic surfactant-based cleanser |
| Clorpactin® | 20.9 | Hypochlorite-based cleanser |
| Coloplast Bedside-Care® Shampoo | 72.7 | Benzethonium chloride-based cleanser |
| Dakin's Solution® (4X diluted) | 0.0 | Sodium hypochlorite-based cleanser |
| Dermagran® | 70.0 | Pyridoxine and Zn-salts—based cleanser |
| DermaKlenz™ | 84.3 | Pyridoxine HCl and alcohol-based cleanser |
| DERMAL WOUND CLEANSER | 52.0 | Non-ionic surfactant and EDTA-based cleanser with benzethonium chloride |
| Dermal Wound Cleanser | 40.0 | EDTA, Amphotheric surfactants |
| Gentell® Wound Cleanser | 63.0 | Amphotheric surfactant-based cleanser |
| HIBICLENS® | >95.0 | CHG and isopropanol-based cleanser |
| Lactated Ringers Solution pH 6.7 | 25.0 | Sodium lactate-based cleanser |
| Microcyn® Rx Skin and Wound HydroGel | 0.0 | Sodium hypochlorite-based cleanser |
| Microcyn® Rx Wound Care Spray | 0.0 | Sodium hypochlorite-based cleanser |
| MicroKlenz™ | 100.0 | Amphotheric surfactant-based cleanser with benzethonium chloride |
| MPM Wound Cleanser | 100.0 | Benzethonium chloride-based cleanser |
| PeleVerus® | 32.0 | Non-ionic surfactant and zinc-salts—based cleanser |
| Puracyn® Plus | 0.0 | Hypochlorous acid (HOCl) in water |
| pure&clean® | 50 | Hypochlorous Acid (HOCl) in water |
| Remedy® | 89.0 | Anionic surfactant-based cleanser |
| REPARA® | 20.0 | Amphotheric surfactant-based cleanser |
| Restore® | 35.18 | Poloxamer-188 and alkyl paraben-based cleanser |
| Shur-Clens® | 0.0 | Poloxamer-188—based cleanser |
| Skintegrity® | 70.0 | Amphotheric surfactant and EDTA-based cleanser |
| Soothe & Cool® Cleanse | 100.0 | EDTA, cationic- and amphotheric-based cleanser |
| UltraKlenz™ | 100.0 | EDTA, non-ionic surfactants |
| VASHE® Wound Solution | 0.0 | Hypochlorite-based cleanser |
| Viniferamine® | 27.5 | Benzalkonium chloride-based cleanser |
| ADAPTIC™ | 5.4 | |
| ALGISITE♢ M | 0.0 | Calcium-alginate dressing |
| ALLEVYN♢ | 0.0 | Hydrocellular dressing |
| AMERIGEL® | 0.0 | Hydrogel dressing |
| Aquasorb® | 0.0 | Hydrogel-polyurethane dressing |
| Biatain® | 1.3 | Soft dressing |
| Bismuth Formic Iodide (BFI) | 75.9 | BFI in talc powder base |
| BlastX™ Antimicrobial Wound Gel | 5.1 | Benzalkonium chloride in PEG |
| Carrasyn® Hydrogel | 0.0 | Carbopol-based hydrogel |
| ColActive® Plus | 0.0 | Collagen-based dressing |
| Covaderm® | 0.0 | Absorbent-adhesive dressing |
| Curasol™ | 0.0 | Hydrogel dressing |
| Cutimed® Sorbact® | 0.0 | Super absorbent dressing |
| Derma Collagen | 20 | Collagen based dressing |
| Dermaginate™ | 0.0 | Calcium alginate-based dressing |
| Drawtex® | 0.0 | Hydroconductive dressing |
| DuoDERM® | 22.0 | CGF dressing |
| DURAFIBER♢ Ag Gelling Fiber Dressing | 0.0 | Cellulose-based dressing |
| Endoform | 0 | |
| Endoform (Natural Dermal Template) | 1.3 | Collagen matrix with glycosaminoglycans and adhesive proteins |
| Enluxtra™ | 30.0 | Super absorbent hydrofiber dressing |
| Exufiber® | 0.0 | PVA fibers |
| Fibracol™ | 2.7 | Collagen-based alginate dressing |
| GlucanPro® Cream 3000 | 69.0 | Petrolatum-based dressing |
| Hydrofera® | 0.0 | Dye-containing bacteriostatic dressing |
| INTRASITE♢ Gel | 0.0 | Cellulose-based hydrogel |
| McKesson Antimicrobial HydroGel | 69.6 | Hypochlorous Acid (HOCl) in water + LiMgNa Silicate |
| Medihoney® | 22.3 | Leptospermum honey dressing |
| Mepilex® | 10.4 | Soft silicone foam dressing |
| Mesalt® | 0.0 | Salt-releasing wound dressing |
| Multidex® Gel | <5.0 | Maltodextrin gel dressing |
| Multipad™ | 0.0 | Non-adherent dressing |
| Normgel® | 39.0 | Hydrogel dressing |
| OASIS® | 6.1 | SIS product |
| Opticell | 0 | Fiber dressing |
| Plurogel® | 0 | Poloxamer and phenoxyethanol gel |
| PROMOGRAN PRISMA™ Matrix | 35.6 | Collagen-based dressing |
| Procellera® | 5.8 | Wound dressing |
| Promogran™ | 22.5 | Collagen-based dressing |
| Prontosan® Gel (10%) | 96.5 | PHMB-containing gel |
| PROSHIELD♢ | 0.0 | PEG-based semi-solid dressing |
| Regenecare® | 100 | Lidocaine Hydrogel |
| RTD™ Dressing | 0.0 | MB, GV, and Ag+ in fiber dressing |
| SAF-Gel® | 2.00 | Hydrogel dressing |
| Simpurity™ | 0.0 | Alginate wound dressing |
| Skintegrity® Hydrogel | 100.0 | Hydrogel dressing |
| Sofsorb® | 0.0 | Super absorbent dressing |
| SOLOSITE♢ Gel | 8.0 | Hydrogel dressing |
| Sorbalgon® | 15.5 | Calcium alginate dressing |
| TheraHoney® | 0.0 | Medicinal honey dressing |
| Theraworx® | 50 | Magnesium Sulfate Attenuator HPUS |
| Transeal® | 0.0 | Transparent film dressing (polyurethane) |
| Xeroform™ | 0.0 | Bismuth in petrolatum gauze |
| IODOFLEX♢ | 93.8 | Iodine dressing |
| IodoFoam® | 2.8 | Complexed iodine in foam dressing |
| Iodoform | 1.6 | Iodoform-impregnated gauze |
| IODOSORB♢ | 87.0 | Iodine gel |
| Benzalkonium chloride | 99.0 | Cationic surfactant antimicrobial |
| Benzethonium chloride | <95.0 | Cationic surfactant antimicrobial |
| Bismuth tribromophenate | 0.0 | Bismuth-based antimicrobial |
| Brilliant green | 20.0 | Antibacterial active |
| CaSO4 powder | 6.0 | Antibacterial carrier |
| Chlorhexidine gluconate | 0.0 | Biguanide-based antimicrobial |
| Colistin sulfate powder | 0.0 | Peptide-based antibacterial |
| Cyclosporine A powder | 0.0 | Anti-inflammatory agent |
| Dapsone powder | 0.0 | Sulfone-based antibacterial |
| Gentamicin sulfate powder | 9.8 | Carbohydrate-based antimicrobial |
| Mafenide acetate powder | 0.0 | Sulfonamide-based antimicrobial |
| Metronidazole powder | 100.0 | Antifungal agent |
| Mupirocin powder | 0.0 | Carbohydrate-based antimicrobial |
| Neomycin powder | 0.0 | Carbohydrate-based antimicrobial |
| pDADMAC (from Bioguard® gauze) | 0.0 | Bacteriostatic polymer |
| pDADMAC (neat) powder | <10.0 | Bacteriostatic polymer |
| Penicillin | 35.0 | beta-lactam antibiotics |
| Polyhexamethylene biguanide (PHMB) powder | 91.0 | Biguanide-based antimicrobial |
| Polysporine® | 1.2 | Protein antimicrobial mixture |
| Silver sulfadiazine | 51.0 | Silver-containing antimicrobial |
| Unasyn® powder | 25.0 | Antibacterial powder |
| Bactroban® Cream | 0.0 | Antibacterial cream |
| Sulfamylon® Cream | 0.0 | Antibacterial cream |
| Gentamicin Sulfate Ointment | 13.0 | Antibacterial cream |
| Kerlix® Gauze (PHMB) | 100.0 | Bacteriostatic gauze |
| Anasept® Gel | 83.0 | Wound dressing |
| Clindamycin Phosphate Gel | 0.0 | Antibacterial hydrogel |
| Cutimed® Sorbact® | 0.0 | Bacteriostatic gauze |
| Zovirax® | 0.0 | Antibacterial cream |
| BACTIGRAS♢ | 0.0 | Parafin dressing |
| ALTABAX® | 20.0 | Antibacterial cream |
| Doxycycline | 100.0 | Antibacterial capsules |
| Vancomycine powder | 68.9 | Antibacterial powder |
| Nitrofurantoin | 60.0 | Antibacterial capsules |
| Ciprofloxacin (tablets and ophthalmic solution) | 100.0 | Antibacterial formulations (tablets or ophthalmic solution) |
| Cephalexin | 15.5 | Antibacterial formulations (tablets) |
| Levofloxacin | 100.0 | Antibacterial formulations (tablets) |
| Americaine® Spray | <2.0 | Benzocaine as an active analgesic in spray base |
| Amphotericin B powder | 85.0 | Antifungal powder |
| Benzocaine | 15.0 | Analgesics active |
| Cell power | 100.0 | Dissolved oxygen with minerals |
| Clobetasol propionate | 0.0 | Anti-inflammatory cream |
| Clotrimazole | 11.0 | Antifungal cream |
| Cyclosporine A | 0.0 | Anti-inflammatory agent |
| Diltiazem HCl | 0 | |
| EMLA® | 0.0 | Mixture of lidocaine and prilocaine in a cream base |
| Fluocinonide (Lidex) | <5.0 | Anti-inflammatory cream |
| Gabapentin (tablets 400mg) | 16.3 | Pain relief tablets |
| Lidocaine (1%) powder | 13.0 | Powder |
| Lidocaine (5%) ointment | 37.5 | Pain relief ointment |
| Metronidazole (Flagyl) | 100.0 | Antifungal cream |
| Miconazole nitrate powder | 70.0 | Antifungal powder |
| Mycophenolate mofetyl | 13.0 | Anti-inflammatory agent |
| Nifedipine | 0.0 | Calcium blocker and chest pain reliever |
| Nystatin cream | 97.8 | Antifungal cream |
| Nystatin powder | 17.2 | Antifungal powder |
| Phenytoin (Dilantin) | <5.0 | Seizure control |
| Sodium thiosulfate | 0.0 | NA |
| Sodium urate | <5.0 | Sodium salt of uric acid |
| Timolol Maleate 0.5% | 0.0 | Ophthalmic agent |
| Triamcinolone Acetonide | 0.0 | Anti-inflammatory cream |
| Vicodin® | 63.0 | Analgesic |