Clinical evidence

Scientifically shown to help advance wounds toward healing

In multiple clinical studies, treatment with Collagenase SANTYL Ointment (in conjunction with sharp debridement) has resulted in faster reduction of wound area.12-14,17

Clinical outcomes associated with serial sharp debridement of diabetic foot ulcers with and without clostridial collagenase ointment This is an external link

SANTYL Ointment + supportive care + sharp debridement showed a 68% average reduction in ulcer area (p<0.001) from baseline at 6 weeks vs. the control group of supportive care* + sharp debridement only, which showed a 36% reduction (p=ns) †‡ from baseline at 6 weeks.12

* Supportive care in the SANTYL Ointment group included ALLEVYN◊ Foam Dressing, cast padding, and Coban bandages.

† All patients agreed to wear an offloading boot or other appropriate device.

‡ Supportive care in the control group was the clinician's choice.

Enzymatic debridement of chronic non-ischemic diabetic foot ulcers: results of a randomized, controlled trial This is an external link

SANTYL Ointment + supportive care*† + sharp debridement showed a 65% mean reduction in ulcer area (p<0.0001) from baseline at 12 weeks vs. the control group of hydrogel + supportive care*† + sharp debridement, which showed a 51% reduction (p<0.0001) from baseline at 12 weeks.13

* Supportive care: ulcers covered with daily foam dressings in both study arms

† All patients agreed to wear an offloading boot or other appropriate device.

Clinical outcomes for diabetic foot ulcers treated with clostridial collagenase ointment or with a product containing silver This is an external link

SANTYL Ointment + supportive care* + periodic sharp debridement† showed a 62% mean reduction ulcer area (n=51) from baseline at six weeks vs. Silver products + supportive care§ + periodic sharp debridement, which showed a 40% reduction (n=51). (p<0.071)17

* Supportive care in the SANTYL Ointment group included ALLEVYN◊ Foam Dressing, cast padding, and Coban or equivalent bandages.

† All subjects underwent sharp debridement prior to the application of the assigned test article and as medically necessary at any of the scheduled study visits.

‡ Product containing silver was the investigator’s choice and was applied according to site procedures and the specific product’s Instructions for Use.

§ Supportive care in the control (silver) group was the clinician’s choice.

¶ SANTYL Ointment is not indicated for the treatment or prevention of infection.

Clinical and economic assessment of diabetic foot ulcer debridement with collagenase: results of a randomized controlled study This is an external link

SANTYL Ointment showed a 45% mean reduction in ulcer area (p=0.016) from baseline at four weeks vs. the group of sharp debridement + wet-to-dry, which showed a 0% reduction (P=ns*) from baseline at four weeks.14

* ns=not significant

SANTYL also delivers more when it comes to cost-effectiveness:

Contact us to learn more about how debridment with SANTYL Ointment delivers more.