Clinical Evidence

Healthcare savings associated with early initiation of SANTYL◊ Ointment

For pressure injury patients

early initiation of SANTYL Ointment resulted in

34% lower

all-cause healthcare costs and

48% lower

disease-specific healthcare costs, compared to patients in which SANTYL Ointment was initiated later.

For diabetic foot ulcer patients

early initiation of SANTYL Ointment resulted in

22% lower

all-cause healthcare costs and

9% lower

disease-specific healthcare costs, compared to patients in which SANTYL Ointment was initiated later.

Early initiation

also resulted in SANTYL Ointment-related

savings of $212

for pressure injury patients and

$129

for diabetic foot ulcer patients.

Overview

  • Retrospective payer claims data from 2007 to 2017 was evaluated based on ICD-9 and ICD-10 (from January 2007 through March 2017), focusing on patients with stage 3 and stage 4 pressure injuries (PIs) or diabetic foot ulcers (DFUs).
  • One-to-one matched cohorts were used to compare all-cause healthcare spending and disease-related health care spending between the early initiation and late initiation groups.
    • Early initiation of SANTYL Ointment: within 30 days of index diagnosis
    • Late initiation of SANTYL Ointment: 31 to 90 days of index diagnosis
  • Patient demographic characteristics – such as age at index diagnosis, gender, race (for Medicare patients only), geographical region and CCI score – were used to match the patients in both patient populations (PI= 1,674 and DFU=2,956).
  • Matched population:
    • PI stage 3 and/or stage 4 diagnosis: Early: N=290, Late: N=290
    • DFU: Early: N=703, Late: N=703
    • Exclusion: Patients who were under 20 years of age at diagnosis or who had SANTYL Ointment prescribed before the index date or 90 days after the index date were excluded.

Results

Stage 3 and 4 pressure injuries

  • All-cause healthcare costs were 34% lower in the early SANTYL Ointment initiation patients compared with late initiation patients.
  • Disease-specific healthcare costs were 48% lower for the early SANTYL Ointment initiation group compared with late initiation patients.
  • Patients in the early SANTYL Ointment initiation group also had a lower average number of SANTYL Ointment-related pharmacy visits and lower SANTYL Ointment-related costs ($408 versus $620).
34% lower
All-cause costs
48% lower
Disease-specific costs

DFUs

  • All-cause healthcare costs in the early SANTYL Ointment initiation group were 22% lower compared with late initiation patients.
  • Disease-specific healthcare costs were 9% lower in the SANTYL Ointment early initiation group compared with late initiation patients.
  • Patients in the early SANTYL Ointment initiation group received an average of 1.63 SANTYL Ointment prescriptions, compared with 1.86 for late initiation patients, and SANTYL Ointment costs were $129 lower per patient in the early initiation group.
22% lower
All-cause costs
9% lower
Disease-specific costs

Read the original research in the August 2020 issue of Wounds here.