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Important Safety Information

Indication: Collagenase SANTYL Ointment is used to remove damaged tissue from chronic skin ulcers and severely burned areas. Do not use if you have shown hypersensitivity to collagenase. Occasional slight redness may occur if SANTYL Ointment is placed outside the wound area. Precautions should be taken to avoid detergents or cleansing solutions that are acidic or basic in nature, as raising or lowering of the Ointment’s pH can lower the effectiveness. Caregivers to debilitated patients should closely monitor the application site to ensure that the area is not becoming infected. The risk information provided herein is not comprehensive. To learn more, talk about SANTYL with your health care provider. The FDA-approved product labeling can be found here. You are encouraged to report negative side effects of prescription drugs to the FDA. Visit MedWatch or call 1-800-FDA-1088.

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Use of this website is governed by the Terms of use, Copyright and disclaimer and Privacy policy. This website is intended for patients and healthcare professionals in the United States only. The information provided is for informational purposes only and is not intended to be medical advice. It does not replace the professional training, experience, and knowledge of the healthcare provider responsible for patient care, who must base treatment upon the unique characteristics of each patient.

If you have questions about using this website, please see the Site map. For questions about SANTYL Ointment that are not answered by this website, contact us.

◇ Trademark of Smith+Nephew. All Trademarks acknowledged.

References

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Sheets AR, Demidova-Rice TN, Shi L, Ronfard V, Grover KV, Herman IM (2016) Identification and Characterization of Novel Matrix-Derived Bioactive Peptides: A Role for Collagenase from Santyl® Ointment in Post-Debridement Wound Healing? PLoS ONE 11(7): e0159598.
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In accordance with USP standards and guidelines and data on file.
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Lehrman, J, Patel A, Delhougne, J. Health Care Spending in Patients With Stage 3 and Stage 4 Pressure Injuries and Patients With Diabetic Foot Ulcers Treated Early With Clostridial Collagenase Ointment: A Retrospective Data Review. Wounds. 2020;32(8):228–236.
Baum, C.L. and Arpey, C.J. Normal cutaneous wound healing: Clinical correlation with cellular and molecular events. Dermatologic Surgery, 2005; 31: 674-686.
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Collagenase SANTYL Ointment [prescribing information]. Fort Worth, TX: Smith & Nephew, Inc.; 2016.
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Hansbrough JF, Achauer B, Dawson J et al. Wound healing in partial-thickness burn wounds treated with collagenase ointment versus silver sulfadiazine cream. J. Burn Care Rehabil. 16(3 Pt 1), 241–247 (1995).
Ostlie DJ, Juang D, Aguayo P et al. Topical silver sulfadiazine vs collagenase ointment for the treatment of partial thickness burns in children: a prospective randomized trial. J. Pediatr. Surg. 47(6), 1204–1207 (2012).
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Carter MJ, Gilligan AM, Waycaster CR, Fife CE. Treating pressure ulcers with clostridial collagenase ointment: results from the US Wound Registry. Wound Repair Regen. 24(5), 904–912 (2016).
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Waycaster C, Milne CT. Clinical and economic benefit of enzymatic debridement of pressure ulcers compared with autolytic debridement with a hydrogel dressing. J. Med. Econ. 16(7), 976–986 (2013).
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Gilligan AM, Waycaster C, Carter MJ, Fife CE. Collagenase ointment for the treatment of venous leg ulcers in outpatient care settings. Presented at: ISPOR 20th Annual International Meeting, May 2015; 16–20.
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Important Safety Information

Indication: Collagenase SANTYL Ointment (“SANTYL”) is indicated for debriding chronic dermal ulcers and severely burned areas. Contraindications: SANTYL is contraindicated in patients who have shown local or systemic hypersensitivity to collagenase. Warnings and Precautions: The optimal pH range of collagenase is 6 to 8. Higher or lower pH conditions will decrease the enzyme’s activity and appropriate precautions should be taken. The enzymatic activity is also adversely affected by certain detergents, and heavy metal ions such as mercury and silver which are used in some antiseptics. As such, the wound should be properly cleansed prior to application of SANTYL. Debilitated patients should be closely monitored for systemic bacterial infections because of the theoretical possibility that debriding enzymes may increase the risk of bacteremia. A slight transient erythema has been noted occasionally in the surrounding tissue, particularly when SANTYL was not confined to the wound. SANTYL is not indicated for wound closure. Discontinue use of SANTYL after granulation tissue is well-established. Adverse Reactions: No allergic sensitivity or toxic reactions have been noted in clinical use when used as directed. The risk information provided herein is not comprehensive. To see the complete Prescribing Information, please see the FDA-approved product labeling, here: https://www.santyl.com/pdf/SANTYL-PI.pdf. You are encouraged to report negative side effects of prescription drugs to the FDA. Visit MedWatch or call 1-800-FDA-1088.

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Use of this website is governed by the Terms of use, Copyright and disclaimer and Privacy policy. This website is intended for patients and healthcare professionals in the United States only. The information provided is for informational purposes only and is not intended to be medical advice. It does not replace the professional training, experience, and knowledge of the healthcare provider responsible for patient care, who must base treatment upon the unique characteristics of each patient.

If you have questions about using this website, please see the Site map. For questions about SANTYL Ointment that are not answered by this website, contact us.

◇ Trademark of Smith+Nephew. All Trademarks acknowledged.