Clears the way for healthy tissue

Collagenase SANTYL Ointment is the only FDA-approved enzymatic debrider. It actively and selectively removes necrotic tissue without harming granulation tissue

Chronic venous leg ulcer images couresy of Robby Wiemer, DPM FACFAS; Mercy Health Center, Philadelphia, PA

Chronic venous leg ulcer images courtesy of Robby Wiemer, DPM FACFAS; Mercy Health Center, Philadelphia, PA

SANTYL® Ointment is enzymatically active by attacking necrotic tissue

Enzymatically active

  • » Continuously and actively removes necrotic tissue to help prevent the reaccumulation of debris that may prolong the healing process

  • » Effectively debrides to allow granulation to proceed and epithelialization to occur

SANTYL® Ointment actively and selectively cleaves nexcrotic tissue without harming granulation tissue

Biologically selective

  • » Selectively attacks and cleaves collagen

  • » Frees the wound of necrotic tissue and cellular debris

  • » Doesn't harm granulation tissue


SANTYL Ointment mechanism of action

  • » In an untreated wound, strands of collagen anchor necrotic tissue to the wound bed

  • » SANTYL Ointment penetrates the wound surface by migrating through the edges of the wound and between pockets of slough, eschar, and dead tissue

  • » SANTYL Ointment selectively attacks this collagen and cleaves the fiber at its attachment point. This detaches the fiber from the wound bed and frees the wound of necrotic debris

  • » After SANTYL Ointment cleaves and degrades the fiber, the necrotic debris can be successfully removed through subsequent cleansing and dressing changes


Collagenase SANTYL Ointment is indicated for debriding chronic dermal ulcers and severely burned areas.

Occasional slight transient erythema has been noted in surrounding tissue when applied outside the wound. One case of systemic hypersensitivity has been reported after 1 year of treatment with collagenase and cortisone. Use of Collagenase SANTYL Ointment should be terminated when debridement is complete and granulation tissue is well established.

For more details, please see complete prescribing information.